Nitric Oxide Synthase Activity in Genetic Hypertension
نویسندگان
چکیده
منابع مشابه
Nitric oxide synthase activity and renal injury in genetic hypertension.
Nitric oxide (NO) is an endogenous vasodilator synthesized in the endothelium by constitutive NO synthase (cNOS). We have shown that upregulation of cNOS activity in hypertension may contribute to forestalling left ventricular and aortic hypertrophy (Hypertension. 29: 235, 1997). NO has been shown to inhibit growth-related responses affecting vascular smooth muscle, and mesangial cells, as well...
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Research on NO in plants has gained considerable attention in recent years mainly due to its function in plant growth and development and as a key signalling molecule in different intracellular processes in plants. The NO emission from plants is known since the 1970s, and now there is abundant information on the multiple effects of exogenously applied NO on different physiological and biochemic...
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Objective(s):Some pathologic situations such as diabetes and metabolic syndrome are associated with alternation in nitric oxide level. Incidence of these condition increases with aging. On the other hand, insulin secretion is modulated by nitric oxide, and nitric oxide synthase (NOS) activity is also altered in diabetes. In this study, modification in the enzyme activity associated with aging a...
متن کاملAssociation between Genetic Variants of Nitric Oxide/cGMP Pathway and Susceptibility to Hypertension in Kermanshah Province
Background and purpose: Hypertension is a global health challenge due to its high prevalence and increased risk of cardiovascular disease. It is a multifactorial disease in which both genetic and environmental factors are involved. So far, a number of genes and pathways have been proposed to be associated with HTN, including the nitric oxide/cGMP pathway. To further clarify the role of NO /cGM...
متن کاملNitric oxide activity in childhood hypertension.
OBJECTIVES To investigate nitric oxide (NO) activity in childhood hypertension using nitrite and nitrate (NOx) concentrations in plasma as an index of nitric oxide generation. DESIGN Cross sectional study. SETTING Tertiary care paediatric centre and district general hospitals in the UK. PATIENTS Children attending the above centre for treatment of hypertension. The control subjects were n...
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ژورنال
عنوان ژورنال: Biochemical and Biophysical Research Communications
سال: 1993
ISSN: 0006-291X
DOI: 10.1006/bbrc.1993.1871